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Polyflux ® Revaclear dialyzer study shows that efficient urea removal can be achieved at lower dialysate flow rates

Dec 09, 2010 12:24 GMT

Previously published results have shown that dialyzer clearance performance is enhanced when dialysate flow rates are increased². However, recent advancements in dialyzer design have improved dialysate flow distribution in the dialyzer.

The objective of the new study was to investigate if there were any significant differences in delivered dialysis dose, as indicated by Kt/V urea, when the dialysate flow rate was set to either 600 ml/min or 800 ml/min using Polyflux Revaclear dialyzers.

The study results showed that there was no statistically significant difference between the two treatment conditions. The conclusion supports the hypothesis that urea removal is not improved when dialysis fluid flow is increased above 600 ml/min when using dialyzers such as the Polyflux Revaclear dialyzer.

“The results show that there is a potential to improve operational efficiency in dialysis clinics, since the same dialysis dose can be delivered using a lower dialysate flow rate,” says Richard A. Ward, PhD.

References:
1. Ward RA, “Increasing dialysate flow rate in dialyzers with enhanced dialysate flow distribution does not increase the delivered dose of dialysis in terms of Kt/Vurea", ASN Renal Week 2010, Denver, USA
2. Ouseph R, Ward RA, “Increasing dialysate flow rate increases dialyzer urea mass transfer area coefficient during clinical use”, Am J Kidney Dis 37:316-320, 2001